Dating the age of admixture via wavelet transform analysis of genome-wide data
Irina PugachMax Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, Germany. [email protected]Rostislav MatveyevMax Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, GermanyAndreas WollsteinMax Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, GermanyManfred KayserMax Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, GermanyMark StonekingMax Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, Germany
2011en
ABI
Аннотация
We describe a PCA-based genome scan approach to analyze genome-wide admixture structure, and introduce wavelet transform analysis as a method for estimating the time of admixture. We test the wavelet transform method with simulations and apply it to genome-wide SNP data from eight admixed human populations. The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species.
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