Optimization of metabolism to improve efficacy during CAR-T cell manufacturing
Meng ZhangFirst Center Clinical College, Tianjin Medical University, Tianjin, 300192, ChinaXin JinDepartment of Hematology, Tianjin First Central Hospital, Tianjin, 300192, ChinaRui SunDepartment of Hematology, Tianjin First Central Hospital, Tianjin, 300192, ChinaXia XiongFirst Center Clinical College, Tianjin Medical University, Tianjin, 300192, ChinaJiaxi WangFirst Center Clinical College, Tianjin Medical University, Tianjin, 300192, ChinaDanni XieFirst Center Clinical College, Tianjin Medical University, Tianjin, 300192, ChinaMingfeng ZhaoDepartment of Hematology, Tianjin First Central Hospital, Tianjin, 300192, China. [email protected]
2021en
ABI
Аннотация
Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological malignancies, there are some problems that remain to be resolved. For example, there are high recurrence rates and poor efficacy in solid tumors. In this review, we first briefly describe the metabolic re-editing of T cells and the changes in metabolism during the preparation of CAR-T cells. Furthermore, we summarize the latest developments and newest strategies to improve the metabolic adaptability and antitumor activity of CAR-T cells in vitro and in vivo.
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