CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
Rodolphe BarrangouDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FranceChristophe FremauxDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FranceHélène DeveauDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FranceMelissa RichardsDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FrancePatrick BoyavalDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FranceSylvain MoineauDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FranceDennis RomeroDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, FrancePhilippe HorvathDanisco France SAS, Boîte Postale 10, F-86220 Dangé-Saint-Romain, France
2007en
ABI
Аннотация
Clustered regularly interspaced short palindromic repeats (CRISPR) are a distinctive feature of the genomes of most Bacteria and Archaea and are thought to be involved in resistance to bacteriophages. We found that, after viral challenge, bacteria integrated new spacers derived from phage genomic sequences. Removal or addition of particular spacers modified the phage-resistance phenotype of the cell. Thus, CRISPR, together with associated cas genes, provided resistance against phages, and resistance specificity is determined by spacer-phage sequence similarity.
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