Статья

Genetic Properties of the Maize Nested Association Mapping Population

Michael D. McMullenDivision of Plant Sciences, University of Missouri, Columbia, MO 65211, USAStephen KresovichInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USAHector Sanchez VilledaDivision of Plant Sciences, University of Missouri, Columbia, MO 65211, USAPeter J. BradburyInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USAHuihui LiInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USAQi SunComputational Biology Service Unit, Cornell University, Ithaca, NY 14853, USASherry Flint-GarcíaDivision of Plant Sciences, University of Missouri, Columbia, MO 65211, USAJeffry M. ThornsberryNorthwest Missouri State University, Maryville, MO 64468, USACharlotte B. AcharyaInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USAChristopher A. BottomsDivision of Plant Sciences, University of Missouri, Columbia, MO 65211, USAPatrick J. BrownInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USAChris BrowneUnited States Department of Agriculture–Agriculture Research Service (USDA–ARS)Magen S. EllerUnited States Department of Agriculture–Agriculture Research Service (USDA–ARS)Kate GuillUnited States Department of Agriculture–Agriculture Research Service (USDA–ARS)Carlos HarjesInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USADallas E. KroonInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USANick LepakUnited States Department of Agriculture–Agriculture Research Service (USDA–ARS)Sharon E. MitchellInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USABrooke PetersonUnited States Department of Agriculture–Agriculture Research Service (USDA–ARS)Gaël PressoirInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USASusan RomeroUnited States Department of Agriculture–Agriculture Research Service (USDA–ARS)Marco Oropeza RosasDepartment of Crop Science, North Carolina State University, Raleigh, NC 27695, USAStella SalvoForeign Agricultural ServiceHeather E. YatesInstitute for Genomic Diversity, Cornell University, Ithaca, NY 14853, USAMark A. HansonIllumina Inc., San Diego, CA 92121, USAElizabeth JonesPioneer Hi-Bred, Johnston, IA 50131, USAStephen J. SmithPioneer Hi-Bred, Johnston, IA 50131, USAJeffrey C. GlaubitzLaboratory of Genetics, University of Wisconsin, Madison, WI 53706, USAM. M. GoodmanDepartment of Crop Science, North Carolina State University, Raleigh, NC 27695, USADoreen WareCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USAJames B. HollandDepartment of Crop Science, North Carolina State University, Raleigh, NC 27695, USAEdward S. BucklerDepartment of Plant Breeding and Genetics, Cornell University, Ithaca, NY 14853, USA

2009en

ABI

Аннотация

Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.

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Идентификаторы

DOI: 10.1126/science.1174320

Цитирования и источники

Цитирований: 4Использованных источников: 0

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