The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
Andrés Moreno‐EstradaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USAChristopher R. GignouxDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USAJuan Carlos Fernández-LópezInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoFouad ZakhariaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USAMartin SikoraDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USAAlejandra ContrerasInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoVíctor Acuña-AlonzoDepartment of Genetics, Evolution and Environment, University College London, London, UKKarla SandovalDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USACeleste EngDepartment of Medicine, University of California, San Francisco, CA, USASandra Romero‐HidalgoInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoPatricia A. Ortiz-TelloDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USAVictoria RoblesDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USAEimear E. KennyDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USAIsmael Nuño‐AranaInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, MexicoRodrigo BarqueraEscuela Nacional de Antropología e Historia (ENAH), Mexico City, MexicoGastón Macín-PérezEscuela Nacional de Antropología e Historia (ENAH), Mexico City, MexicoJulio GranadosInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoScott HuntsmanDepartment of Medicine, University of California, San Francisco, CA, USAJoshua GalanterDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USAMarc VíaDepartment of Medicine, University of California, San Francisco, CA, USAJean G. FordThe Brooklyn Hospital Center, Brooklyn, NY, USARocío ChapelaInstituto Nacional de Enfermedades Respiratorias (INER), Mexico City, MexicoWilliam Rodríguez-CintrónVeterans Caribbean Health Care System, San Juan, Puerto RicoJosé Rodríguez‐SantanaDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USAIsabelle RomieuInternational Agency for Research on Cancer, Lyon, FranceJuan José Luis Sienra-MongeHospital Infantil de México Federico Gomez, Mexico City, MexicoBlanca del Río NavarroHospital Infantil de México Federico Gomez, Mexico City, MexicoStephanie J. LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USAAndrés Ruiz‐LinaresDepartment of Genetics, Evolution and Environment, University College London, London, UKRodrigo García-HerreraInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoKarol EstradaInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoAlfredo Hidalgo‐MirandaInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoGerardo Jiménez‐SánchezInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoAlessandra CarnevaleInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoXavier SoberónInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoSamuel Canizales‐QuinterosFacultad de Química, Universidad Nacional Autónoma de México, Mexico City, MexicoHéctor Rangel‐VillalobosInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, MexicoIrma Silva‐ZolezziInstituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoEsteban G. BurchardDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USACarlos D. BustamanteDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA
2014en
ABI
Аннотация
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.
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