Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance
Juan Camilo Chacón-DuqueDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UKKaustubh AdhikariDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UKMacarena Fuentes‐GuajardoDepartamento de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad de Tarapacá, Arica, 1000009, ChileJavier Mendoza‐RevillaDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UKVíctor Acuña-AlonzoDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UKRodrigo BarqueraDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, GermanyMirsha Quinto‐SánchezCiencia Forense, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, 04510, MexicoJorge Gómez‐ValdésPosgrado en Antropología Física, Escuela Nacional de Antropología e Historia, Mexico City, 14030, MexicoPaola EverardoPosgrado en Antropología, Universidad Nacional Autónoma de México, Mexico City, 04510, MexicoHugo Villamil‐RamírezUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México e Instituto Nacional de Medicina Genómica, Mexico City, 04510, MexicoTábita HünemeierDepartamento de Genética e Biología Evolutiva, Instituto de Biociências, Universidade de São Paulo, Sao Paulo, 05508-090, BrazilVirgínia RamalloDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, BrazilCaio César Silva de CerqueiraDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, BrazilMalena HurtadoLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, PeruValeria VillegasLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, PeruVanessa GranjaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, PeruMercedes VillenaInstituto Boliviano de Biología de Altura (IBBA), Universidad Mayor de San Andrés (UMSA), La Paz, 2070, BoliviaRené VásquezInstituto Boliviano de Biología de Altura (IBBA), Universidad Autónoma Tomás Frías, Potosí, 53820, BoliviaElena LlopPrograma de Genetica Humana, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, 1027, ChileJosé R. SandovalFacultad de Medicina Humana, Universidad de San Martín de Porres, Lima, 12, PeruAlberto Salazar‐GranaraFacultad de Medicina Humana, Universidad de San Martín de Porres, Lima, 12, PeruMaría Laura ParolínInstituto de Diversidad y Evolución Austral (IDEAus), Centro Nacional Patagónico, CONICET, Puerto Madryn, U912OACD, ArgentinaKarla SandovalNational Laboratory of Genomics and Biodiversity (LANGEBIO), CINVESTAV, Irapuato, 36821, MexicoRosenda I. Peñaloza‐EspinosaDepartment of Biological Systems, Division of Biological and Health Sciences, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, 04960, MexicoHéctor Rangel‐VillalobosInstituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, 1115, MexicoCheryl A. WinklerBasic Research Laboratory, National Cancer Institute, Frederick National Laboratory, Frederick, MD, 21702, USAWilliam KlitzIntegrative Biology, University of California, Berkeley, CA, 94720, USACláudio M. BraviInstituto Multidisciplinario de Biología Celular, CONICET, La Plata, B1906APO, ArgentinaJulio MolinaCentro de Investigaciones Biomédicas de Guatemala, Ciudad de Guatemala, 01011, GuatemalaDaniel CorachServicio de Huellas Digitales Genéticas and CONICET, Universidad de Buenos Aires, Buenos Aires, C1113AAD, ArgentinaRamiro BarrantesEscuela de Biología, Universidad de Costa Rica, San José, 2060, Costa RicaVerónica GomesInstituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, 4200-135, PortugalCarlos ResendeInstituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, 4200-135, PortugalLeonor GusmãoDNA Diagnostic Laboratory (LDD), Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 23968-000, BrazilAntónio AmorimFaculdade de Ciências, Universidade do Porto, Porto, 4169-007, PortugalYali XueThe Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UKJean‐Michel DugoujonCentre National de la Recherche Scientifique, Université Toulouse 3 Paul Sabatier, Toulouse, 31330, FrancePedro MoralDepartamento de Biología Evolutiva, Ecología y Ciencias Ambientales, Universitat de Barcelona, Barcelona, 08007, SpainRolando González‐JoséInstituto Patagónico de Ciencias Sociales y Humanas-Centro Nacional Patagónico, CONICET, Puerto Madryn, U912OACD, ArgentinaLavínia Schüler‐FacciniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, BrazilFrancisco M. SalzanoDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, BrazilMaría Cátira BortoliniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 91501-970, BrazilSamuel Canizales‐QuinterosUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México e Instituto Nacional de Medicina Genómica, Mexico City, 04510, MexicoGiovanni PolettiLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, PeruCarla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, PeruGabriel BedoyaGenética Molecular (GENMOL), Universidad de Antioquia, Medellín, 5001000, ColombiaFrancisco RothhammerInstituto de Alta Investigación, Universidad de Tarapacá, Arica, 1000009, ChileDavid J. BaldingDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UKGarrett HellenthalDepartment of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London, WC1E 6BT, UK. [email protected]Andrés Ruiz‐LinaresAix-Marseille Univ, CNRS, EFS, ADES, Marseille, 13007, France. [email protected]
2018en
ABI
Аннотация
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.
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