Обзорная статья

Photodynamic therapy of cancer: An update

Patrizia AgostinisDepartment of Molecular Cell Biology, Cell Death Research and Therapy Laboratory, Catholic University of Leuven, BelgiumKristian BergProfessor and Head of the Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway;Keith A. CengelAssistant Professor of Radiation Oncology at the Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA;Thomas H. FosterProfessor of Imaging Sciences, Department of Imaging Sciences, University of Rochester, Rochester, NY;Albert W. GirottiProfessor of Biochemistry at the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI;Sandra O. GollnickProfessor of Oncology, Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY;Stephen M. HahnHenry K. Pancoast Professor and Chairman of the Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA;Michael R. HamblinAssociate Professor of Dermatology, Department of Dermatology, Harvard Medical School, Boston, MAAsta JuzenienePostdoctoral Fellow at the Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway;David KesselProfessor of Pharmacology, Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI;Mladen KorbelikDistinguished Scientist, Integrative Oncology Department, British Columbia Cancer Agency, Vancouver, British Columbia, Canada;Johan MoanProfessor of Physics, Group of Plasma and Space Physics, Institute of Physics, University of Oslo, Oslo, Norway;Paweł MrózInstructor in Dermatology, Department of Dermatology, Harvard Medical School, Boston, MADominika NowisAssistant Professor at the Department of Immunology, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland;Jacques PietteDirector of GIGA-Research, Laboratory of Virology and Immunology, Professor at the University of Lie `ge, Lie `ge, Belgium;Brian C. WilsonHead of the Division of Biophysics and Imaging, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada;Jakub GołąbProfessor of Immunology and Head of the Department of Immunology, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland;

2011en

ABI

Аннотация

Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.

Перевод пока недоступен

Идентификаторы

DOI: 10.3322/caac.20114

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar