Rational design of flexible microneedles coupled with CaO<sub>2</sub>@PDA-loaded nanofiber films for skin wound healing on diabetic rats
Zhiyong ZengSchool of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaGuohua JiangInternational Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou, 310018, ChinaYanfang SunCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018, ChinaUladzislau E. AharodnikauResearch Institute for Physical Chemical Problems of the Belarusian State University, Minsk, 220030, BelarusKhaydar E. YunusovInstitute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Tashkent, 100128, UzbekistanXiaofei GaoSchool of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaTianqi LiuSchool of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaSergey O. SolomevichResearch Institute for Physical Chemical Problems of the Belarusian State University, Minsk, 220030, Belarus
ABI
Аннотация
@PDA nanoparticles demonstrated a high level of CD31 and low level of TNF-α, leading to accelerated diabetic skin-wound closure. These distinctive features demonstrate that our microneedle system can be a facile candidate for efficient wound healing in patients with diabetes and may be applied in various biomedical fields.
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