Обзорная статья

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

Zhiliang ChengDepartment of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USAAjlan Al ZakiDepartment of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USAJames Z. HuiDepartment of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USAVladimir R. MuzykantovInstitute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, TRC 10-125, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104, USAAndrew TsourkasDepartment of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA

2012en

ABI

Аннотация

Nanoparticle-based drug delivery systems have been developed to improve the efficacy and reduce the systemic toxicity of a wide range of drugs. Although clinically approved nanoparticles have consistently shown value in reducing drug toxicity, their use has not always translated into improved clinical outcomes. This has led to the development of "multifunctional" nanoparticles, where additional capabilities like targeting and image contrast enhancement are added to the nanoparticles. However, additional functionality means additional synthetic steps and costs, more convoluted behavior and effects in vivo, and also greater regulatory hurdles. The trade-off between additional functionality and complexity is the subject of ongoing debate and the focus of this Review.

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Идентификаторы

DOI: 10.1126/science.1226338

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar