Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. KunkleJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. [email protected]The European Alzheimer’s Disease Initiative (EADI),Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceBenjamin Grenier‐BoleyInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceRebecca SimsDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKJoshua C. BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAVincent DamotteInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceAdam C. NajDepartment of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAAnne BolandCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceMaria VronskayaDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKSven J. van der LeeDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsAlexandre Amlie‐WolfPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USACéline BellenguezInserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, FranceAura FrizattiDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKVincent ChourakiDepartment of Neurology, Boston University School of Medicine, Boston, MA, USAEden R. MartinJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USAKristel SleegersLaboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, BelgiumNandini BadarinarayanDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKJóhanna JakobsdóttirIcelandic Heart Association, Kopavogur, IcelandKara L. Hamilton‐NelsonJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USASonia Moreno–GrauCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, SpainRobert OlasoCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceRachel RaybouldDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKYuning ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USAAmanda B KuzmaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMikko HiltunenDepartment of Neurology, Kuopio University Hospital, Kuopio, FinlandTaniesha MorganDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKShahzad AhmadDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsBadri N. VardarajanDepartment of Neurology, Columbia University, New York, NY, USAJacques EpelbaumUMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, FrancePer HoffmannDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, GermanyMerçé BoadaCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, SpainGary W. BeechamJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USAJean-Guillaume GarnierCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceDenise HaroldSchool of Biotechnology, Dublin City University, Dublin, IrelandAnnette L. FitzpatrickDepartment of Epidemiology, University of Washington, Seattle, WA, USAOtto ValladaresPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMarie-Laure MoutetCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceAmy GerrishDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UKAlbert V. SmithDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USALiming QuPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USADelphine BacqCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceNicola DenningDivision of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKXueqiu JianBrown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USAYi ZhaoPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMaria Del ZompoSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyNick C. FoxDementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UKSeung‐Hoan ChoiFundació ACEIgnacio MateoNeurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, SpainJoseph T. HughesDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKHieab H.H. AdamsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsJohn MalamonPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAFlorentino Sánchez-GarcíaDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, SpainYogen PatelDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKJennifer A. BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USABeth A. DombroskiPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMaría Cándida Déniz NaranjoDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, SpainMakrina DaniilidouDepartment of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GreeceGuðný EiríksdóttirIcelandic Heart Association, Kopavogur, IcelandShubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, USADavid WallonNormandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, FranceJames UphillDepartment of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UKThor AspelundCentre for Public Health, University of Iceland, Reykjavik, IcelandLaura B. CantwellPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAFabienne GarziaCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceDaniela GalimbertiFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, ItalyEdith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, AustriaMariusz ButkiewiczInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USABertrand FinCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceElio ScarpiniFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, ItalyChloé SarnowskiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USAWilliam S. BushInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USAStéphane MeslageCentre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, FranceJohannes KornhuberDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, GermanyCharles C. WhiteProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USAYuenjoo SongInstitute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USARobert C. BarberDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USASebastiaan EngelborghsDepartment of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, BelgiumSabrina SordonDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, GermanyDina VoijnovicDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsPerrie M. AdamsDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USARik VandenbergheLaboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, BelgiumManuel MayhausDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, GermanyL. Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USAMarilyn S. AlbertDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USAPeter Paul De DeynDepartment of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, BelgiumWei GuDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, GermanyJ.J. HimaliDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USADuane BeeklyNational Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USAAlessio SquassinaSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyAnnette M. HartmannDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, GermanyAdelina OrellanaResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, SpainDeborah BlackerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USAEloy Rodríguez‐RodríguezNeurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, SpainSimon LovestoneDepartment of Psychiatry, University of Oxford, Oxford, UKMelissa E. GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USARachelle S. DoodyAlzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USACarmen Munoz-FernadezDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, SpainRebecca SussamsDivision of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UKHonghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USAThomas FairchildOffice of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA
2019en
ABI
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