A Simple Synthesis of Rutaecarpine
Yurngdong JahngCollege of Pharmacy, Yeungnam University, Kyongsan 712-749, KoreaSeung Ho LeeCollege of Pharmacy, Yeungnam University, Kyongsan 712-749, KoreaSeung Ill KimCollege of Pharmacy, Yeungnam University, Kyongsan 712-749, KoreaJae Gyu ParkCollege of Pharmacy, Yeungnam University, Kyongsan 712-749, KoreaEung Seok LeeCollege of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea
2001en
ABI
Аннотация
Indoloquinazoline alkaloid rutaecarpine was efficiently synthesized by employing 9,10,11,12-tetrahydro-4H-pyrido[2,1-b]quinazoline-4,9-dione as a key intermediate, whose 9-carbonyl group was introduced by benzylidene formation, followed by ozonolysis.Rutaecarpine ( 1) is one of the indoloquinazoline alkaloids of the Rutaceous plants such as Evodia rutaecarpa which has long been utilized for the treatment of inflammation-related disorders in the
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