Статья

Core–Shell Microneedle Gel for Self-Regulated Insulin Delivery

Jinqiang WangDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesYanqi YeDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesJicheng YuDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesAnna R. KahkoskaDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United StatesXudong ZhangDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesChao WangDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesWujin SunDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesRia D. CorderDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, United StatesZhaowei ChenDivision of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United StatesSaad A. KhanDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, United StatesJohn B. BuseDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United StatesZhen GuDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, United States

2018en

ABI

Аннотация

A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a painless core–shell microneedle array patch consisting of degradable cross-linked gel for smart insulin delivery with rapid responsiveness and excellent biocompatibility. This gel-based device can partially dissociate and subsequently release insulin when triggered by hydrogen peroxide (H2O2) generated during the oxidation of glucose by a glucose-specific enzyme covalently attached inside the gel. Importantly, the H2O2-responsive microneedles are coated with a thin-layer embedding H2O2-scavenging enzyme, thus mimicking the complementary function of enzymes in peroxisomes to protect normal tissues from injury caused by oxidative stress. Utilizing a chemically induced type 1 diabetic mouse model, we demonstrated that this smart insulin patch with a bioresponsive core and protective shell could effectively regulate the blood glucose levels within a normal range with improved biocompatibility.

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Идентификаторы

DOI: 10.1021/acsnano.7b08152

Цитирования и источники

Цитирований: 2Использованных источников: 0

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