Stimuli-responsive transdermal microneedle patches
Pooyan MakvandiIstituto Italiano di Tecnologia, Centre for Materials interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, ItalyRezvan JamaledinCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyGuojun ChenDepartment of Bioengineering and California NanoSystems Institute, University of California, Los Angeles, CA, 90095, USAZahra BaghbantaraghdariCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyEhsan Nazarzadeh ZareSchool of Chemistry, Damghan University, Damghan, 36716-41167, IranConcetta Di NataleUniversity of Naples Federico IIValentina OnestoCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyRaffaele VecchioneCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyJesse LeeDepartment of Biomedical Engineering, and the Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, H3G 0B1, CanadaFranklin R. TayCollege of Graduate Studies, Augusta University, Augusta, GA, 30912, USAPaolo A. NettiCenter for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, ItalyVirgilio MattoliIstituto Italiano di Tecnologia, Centre for Materials interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, ItalyAna JaklenecDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USAZhen GuCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR ChinaRóbert LangerDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
2021en
ABI
Аннотация
Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.
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