Обзорная статья

RETRACTED: New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities

Milad AshrafizadehFaculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956 Istanbul, Turkey; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956 Istanbul, TurkeySepideh MirzaeiDepartment of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, IranFarid HashemiDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranAli ZarrabiSabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956 Istanbul, TurkeyAmirhossein ZabolianYoung Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, IranHossein SalekiYoung Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, IranSeyed Omid SharifzadehYoung Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, IranLeyla SoleymaniDepartment of Biology, Faculty of Science, Urmia University, Urmia, IranSalman DaneshiDepartment of Public Health, School of Health, Jiroft University of Medical Sciences, Jiroft, IranKiavash HushmandiDepartment of Food Hygiene and Quality Control, Division of epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranHaroon KhanDepartment of Pharmacy, Abdul Wali Khan University, Mardan 23200, PakistanAlan Prem KumarCancer Science Institute of Singapore and Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117599, Singapore; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore. Electronic address: [email protected]Amir Reza ArefBelfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Vice President at Translational Sciences, Xsphera Biosciences Inc. 6 Tide Street, Boston, MA 02210, USASaeed SamarghandianNoncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: [email protected]

2021en

ABI

Аннотация

Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells are transformed to mesenchymal cells, and at molecular level, E-cadherin undergoes down-regulation, while an increase occurs in N-cadherin and vimentin levels. Increasing evidence demonstrates role of EMT in mediating drug resistance of cancer cells. On the other hand, paclitaxel (PTX) and docetaxel (DTX) are two chemotherapeutic agents belonging to taxene family, capable of inducing cell cycle arrest in cancer cells via preventing microtubule depolymerization. Aggressive behavior of cancer cells resulted from EMT-mediated metastasis can lead to PTX and DTX resistance. Upstream mediators of EMT such as ZEB1/2, TGF-β, microRNAs, and so on are involved in regulating response of cancer cells to PTX and DTX. Tumor-suppressing factors inhibit EMT to promote PTX and DTX sensitivity of cancer cells. Furthermore, three different strategies including using anti-tumor compounds, gene therapy and delivery systems have been developed for suppressing EMT, and enhancing cytotoxicity of PTX and DTX against cancer cells that are mechanistically discussed in the current review.

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Идентификаторы

DOI: 10.1016/j.biopha.2021.111824

Цитирования и источники

Цитирований: 3Использованных источников: 0

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