Обзорная статья

The Therapeutic Potential of Apigenin

Bahare SalehiStudent Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, IranAlessandro VendittiDipartimento di Chimica, “Sapienza” Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, ItalyMehdi Sharifi‐RadDepartment of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663-335, IranDorota KręgielInstitute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, PolandJavad Sharifi‐RadFood Safety Research Center (salt), Semnan University of Medical Sciences, Semnan 35198-99951, IranAlessandra DurazzoMassimo LucariniAntonello SantiniDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, ItalyEliana B. SoutoCEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, PortugalEttore NovellinoDepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, ItalyHubert AntolakInstitute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, PolandElena AzziniWilliam N. SetzerDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USANatália MartinsFaculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

2019en

ABI

Аннотация

Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer's disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin's key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.

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Идентификаторы

DOI: 10.3390/ijms20061305

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar