Статья

Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

Aaron S. Schwartz‐DuvalBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USAChristian J. KonopkaBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USAParikshit MoitraDepartment of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, Interdisciplinary Health Sciences Facility, 1000 Hilltop Circle Baltimore, Baltimore, MD, 21250, USAEnrique DazaBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USAIndrajit SrivastavaBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USAElyse JohnsonTaylor L. KampertBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USAStanley FaynBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USAAnand HaranBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USALawrence W. DobruckiBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USADipanjan PanBeckman Institute, University of Illinois, Urbana-Champaign, Urbana, IL, 61801, USA. [email protected]

2020en

ABI

Аннотация

Various cancer cells have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid is introduced to their cellular microenvironment. But their biomedical applications are limited, particularly considering the millimolar concentrations and longer incubation period of ionic gold. Here, we describe a simplistic method of intracellular biomineralization to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application utilizing polyethylene glycol as delivery vector for ionic gold. We have characterized this process for intracellular gold nanoparticle formation, which progressively accumulates proteins as the ionic gold clusters migrate to the nucleus. This nano-vectorized application of ionic gold emphasizes its potential biomedical opportunities while reducing the quantity of ionic gold and required incubation time. To demonstrate its biomedical potential, we further induce in-situ biosynthesis of gold nanoparticles within MCF7 tumor mouse xenografts which is followed by its photothermal remediation.

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Идентификаторы

DOI: 10.1038/s41467-020-17595-6

Цитирования и источники

Цитирований: 2Использованных источников: 0

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