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Evidence-based clinical practice guidelines for inflammatory bowel disease 2020

Hiroshi NakaseDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, S-1, W-16, Chuoku, Sapporo, Hokkaido, 060-8543, Japan. [email protected]Motoi UchinoGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanShinichiro ShinzakiGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanMinoru MatsuuraGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanKatsuyoshi MatsuokaGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanTaku KobayashiGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanMasayuki SarutaGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanFumihito HiraiGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanKeisuke HataGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanSakiko HiraokaGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanMotohiro EsakiGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanKen SugimotoGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanToshimitsu FujiGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanKenji WatanabeGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanShirô NakamuraGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanNagamu InoueGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanToshiyuki ItohGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanMakoto NaganumaGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanTadakazu HisamatsuGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanMamoru WatanabeGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanHiroto MiwaGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanNobuyuki EnomotoGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanTooru ShimosegawaGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, JapanKazuhiko KoikeGuidelines Committee for Creating and Evaluating the "Evidence-Based Clinical Practice Guidelines for Inflammatory Bowel Disease", The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo, 105-0004, Japan
2021en
ABI

Аннотация

Abstract Inflammatory bowel disease (IBD) is a general term for chronic or remitting/relapsing inflammatory diseases of the intestinal tract and generally refers to ulcerative colitis (UC) and Crohn’s disease (CD). Since 1950, the number of patients with IBD in Japan has been increasing. The etiology of IBD remains unclear; however, recent research data indicate that the pathophysiology of IBD involves abnormalities in disease susceptibility genes, environmental factors and intestinal bacteria. The elucidation of the mechanism of IBD has facilitated therapeutic development. UC and CD display heterogeneity in inflammatory and symptomatic burden between patients and within individuals over time. Optimal management depends on the understanding and tailoring of evidence-based interventions by physicians. In 2020, seventeen IBD experts of the Japanese Society of Gastroenterology revised the previous guidelines for IBD management published in 2016. This English version was produced and modified based on the existing updated guidelines in Japanese. The Clinical Questions (CQs) of the previous guidelines were completely revised and categorized as follows: Background Questions (BQs), CQs, and Future Research Questions (FRQs). The guideline was composed of a total of 69 questions: 39 BQs, 15 CQs, and 15 FRQs. The overall quality of the evidence for each CQ was determined by assessing it with reference to the Grading of Recommendations Assessment, Development and Evaluation approach, and the strength of the recommendation was determined by the Delphi consensus process. Comprehensive up-to-date guidance for on-site physicians is provided regarding indications for proceeding with the diagnosis and treatment.

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