A Phenylboronate‐Functionalized Polyion Complex Micelle for ATP‐Triggered Release of siRNA
Mitsuru NaitoDepartment of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656, JapanTakehiko IshiiDepartment of Bioengineering, The University of Tokyo (Japan)Akira MatsumotoInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)Kanjiro MiyataDivision of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo (Japan)Yuji MiyaharaInstitute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)Kazunori KataokaDepartment of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/
2012en
ABI
Аннотация
PIC-ing a winner: siRNA encapsulated by a phenylboronate-functionalized polyion complex (PIC) micelle shows binding between the phenylboronate and the 3′ ribose of the siRNA (see scheme), stabilizing the complex under conditions equivalent to the extracellular environment. This complex is disrupted in response to addition of ATP, at a concentration comparable to that inside cells.
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