Статья

1,1-Diphenyl,2-picrylhydrazyl free radical scavenging, bactericidal, fungicidal and leishmanicidal properties of <i>Teucrium stocksianum</i>

Syed Majid ShahDepartment of Chemistry, Kohat University of Science and Technology, Kohat, PakistanMuhammad AyazDepartment of Pharmacy, Kohat University of Science and Technology, Kohat, PakistanArif‐ullah KhanDepartment of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, PakistanFarhat UllahDepartment of Pharmacy, University of Malakand, Dir (L), PakistanFarhanDepartment of Chemistry, Kohat University of Science and Technology, Kohat, PakistanAzhar-ul-Haq Ali ShahDepartment of Chemistry, Kohat University of Science and Technology, Kohat, PakistanHamid IqbalDepartment of Microbiology, Kohat University of Science and Technology, Kohat, PakistanSajid HussainDepartment of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan

2013en

ABI

Аннотация

In the present study, we evaluated the pharmacological and toxicological effects of Teucrium stocksianum. The crude extract of T. stocksianum (Ts.Cr) and its subsequent organic fractions: n-hexane (Ts.Hex), chloroform (Ts.CHCl3) and ethyl acetate (Ts.EtAc) exhibited 1,1-diphenyl,2-picrylhydrazyl free radical scavenging activity with different potencies. Ts.EtAc was found to be most potent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc showed significant bactericidal activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, Shigella flexneri and Bacillus subtilis at their extent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc displayed fungicidal action against Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Fusarium solani at various minimum inhibitory concentrations. Ts.Cr and Ts.EtAc exhibited marked inhibition of Leishmania tropica growth, observed after 48 and 96 hrs of treatment. These data indicate that the T. stocksianum methanolic extract and its resultant fractions possess antioxidant, antibacterial, antifungal and antileishmanial activities. Thus, the present research unearths the scientific base for T. stocksianum medicinal application as antioxidant and antimicrobial agents.

Перевод пока недоступен

Идентификаторы

DOI: 10.1177/0748233713487250

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar