Cycloartane Triterpene Glycosides from the Roots of<i>Astragalus melanophrurius</i>
İhsan ÇalışHacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, TR-06100 Ankara, TurkeyAyşen YürükerHacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, TR-06100 Ankara, TurkeyDeniz TaşdemirDepartment of Pharmacy, Swiss Federal Institute of Technology ETH Zurich, CH-8057 Zürich, SwitzerlandAnthony WrightDepartment of Pharmacy, Swiss Federal Institute of Technology ETH Zurich, CH-8057 Zürich, SwitzerlandOtto SticherDepartment of Pharmacy, Swiss Federal Institute of Technology ETH Zurich, CH-8057 Zürich, SwitzerlandYing-De LuoProgram for Collaborative Research, College of Pharmacy, University of Illinois at Chicago, Chicago, U.S.AJohn M. PezzutoProgram for Collaborative Research, College of Pharmacy, University of Illinois at Chicago, Chicago, U.S.A
1997en
ABI
Аннотация
From the roots of Astragalus melanophrurius eight known saponins (1-8) were isolated. Based on spectral data (IR, 1H- and 13C-NMR, and FABMS), the structures were established as astrasieversianins II (1) and X (4), astragalosides I (2), II (3), IV (5) and VI (7), and cyclocanthosides E (6) and G (8). The isolates were evaluated in a broad range of bioassay systems and found to be inactive. Modest antibacterial activity was observed, however, as was immunomodulatory activity, as indicated by stimulation of isolated human lymphocytes.
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