27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
Erik R. NelsonDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USASuzanne E. WardellDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USAJeff S. JasperDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USASung Hee ParkDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USASunil SuchindranDuke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USAMatthew K. HoweDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USANicole J. CarverDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USARuchita V. PillaiDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USAPatrick M. SullivanDivision of Geriatrics, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USAVarun SondhiDepartments of Pediatrics and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USAMichihisa UmetaniDepartments of Pediatrics and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USAJoseph GeradtsDepartment of Pathology, Duke University School of Medicine, Durham, NC 27710, USADonald P. McDonnellDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA
2013en
ABI
Аннотация
Cholesterol and Cancer Obesity and high cholesterol levels are associated with an increased risk of breast cancer in post-menopausal women. Nelson et al. (p. 1094 ) found that a specific metabolite of cholesterol, 27-hydroxycholesterol (27HC), promoted tumor growth and metastasis in mouse models of mammary cancer by serving as a partial agonist for the estrogen receptor and the liver X receptor. The most aggressive human breast cancers were found to express the highest level of the enzyme that converts cholesterol to 27HC, suggesting that 27HC produced within tumors (in addition to circulating 27HC) may contribute to tumorigenesis.
Перевод пока недоступен
Идентификаторы
Цитирования и источники
Цитирований: 2Использованных источников: 0