Boswellic acids: privileged structures to develop lead compounds for anticancer drug discovery
Hidayat HussainDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg, GermanyIftikhar AliDepartment of Chemistry, Karakoram International University, Gilgit, PakistanDaijie WangSchool of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, ChinaFaruck Lukmanul HakkimDepartment of Urology Masonic Cancer Center, University of Minnesota (Twin Cities), Minneapolis, USABernhard WestermannDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg, GermanyLuay RashanMedicinal Plants Division, Research Center, Dhofar University, Salalah, OmanIshtiaq AhmedDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UKIvan R. GreenDepartment of Chemistry and Polymer Science, University of Stellenbosch, Stellenbosch, South Africa
2021en
ABI
Аннотация
: Numerous semisynthetic BAs illustrate excellent cytotoxic effects. Of note, compounds bearing cyanoenone moieties in ring A, endoperoxides and hybrids display increased and more potent cytotoxic effects compared with other semisynthetic BAs. Moreover, BAs have the potential to conjugate or couple with other anticancer compounds to synergistically increase their combined anticancer effects. In addition, to get derived BAs to become lead anticancer compounds, future research should focus on the preparation of ring A cyanoenones, endoperoxides, and C-24 amide analogs.
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