Обзорная статья

Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Maomao XieState Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou Medical College Soochow University Suzhou 215123 Jiangsu ChinaMeng GaoState Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou Medical College Soochow University Suzhou 215123 Jiangsu ChinaYang YunCollege of Environmental & Resource Sciences Shanxi University Taiyuan 030006 Shanxi ChinaMartin MalmstenDepartment of Pharmacy University of Copenhagen 2100 Copenhagen DenmarkVincent M. RotelloDepartment of Chemistry University of Massachusetts Amherst 710 N. Pleasant St. Amherst USARadek ZbořilNanotechnology Centre Centre of Energy and Environmental Technologies VŠB-Technical University of Ostrava 17. listopadu 2172/15 Ostrava-Poruba 708 00 Czech RepublicOmid AkhavanCondensed Matter National Laboratory P.O. Box 1956838861 Tehran IranAliaksandr KraskouskiDepartment of Physicochemistry of Thin Film Materials Institute of Chemistry of New Materials of NAS of Belarus 36 F. Skaryna Str. 220084 Minsk BelarusJohn AmalrajLaboratory of Materials Science Instituto de Química de Recursos Naturales Universidad de Talca P.O. Box 747 Talca ChileXiaoming CaiSchool of Public Health Suzhou Medical College Soochow University Suzhou Jiangsu 215123 ChinaJianmei LuCollege of Chemistry Chemical Engineering and Materials Science National Center for International Research on Intelligent Nano-Materials and Detection Technology in Environmental Protection Soochow University Suzhou 215123 ChinaHuizhen ZhengState Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou Medical College Soochow University Suzhou 215123 Jiangsu ChinaRuibin LiState Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou Medical College Soochow University Suzhou 215123 Jiangsu China

2023en

ABI

Аннотация

Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.

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Идентификаторы

DOI: 10.1002/anie.202217345

Цитирования и источники

Цитирований: 2Использованных источников: 0

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