Статья

Wild Mushrooms in Nepal: Some Potential Candidates as Antioxidant and ACE‐Inhibition Sources

Tran Hai BangFaculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan ; Department of Chemistry, Hue College of Sciences, Hue University, 77 Nguyen Hue, Hue, VietnamHiroto SuharaMiyazaki Prefectural Wood Utilization Research Center, Miyazaki 885-0037, JapanKatsumi DoiFaculty of Agriculture, Kyushu University, Fukuoka 812-8581, JapanHiroya IshikawaInternational College of Arts and Sciences, Fukuoka Women's University, Fukuoka 813-8529, JapanKatsuya FukamiMaterial Management Center, Kyushu University, Fukuoka 812-8581, JapanGopal Prasad ParajuliPlant Pathology Division, Nepal Agriculture Research Council, Khumaltar, Lalitpur, Nepal, P.O. Box. 3605, Kathmandu, NepalYoshinori KatakuraFaculty of Agriculture, Kyushu University, Fukuoka 812-8581, JapanShuntaro YamashitaGraduate School of Systems Life Sciences, Kyushu University, Fukuoka 812-8581, JapanKazuo WatanabePlant Pathology Division, Nepal Agriculture Research Council, Khumaltar, Lalitpur, Nepal, P.O. Box. 3605, Kathmandu, NepalM. K. AdhikariHira Kaji ManandharPlant Pathology Division, Nepal Agriculture Research Council, Khumaltar, Lalitpur, Nepal, P.O. Box. 3605, Kathmandu, NepalRyuichiro KondoFaculty of Agriculture, Kyushu University, Fukuoka 812-8581, JapanKuniyoshi ShimizuFaculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan

2014en

ABI

Аннотация

Twenty-nine mushrooms collected in the mountainous areas of Nepal were analyzed for antioxidant activity by different methods, including Folin-Ciocalteu, ORAC, ABTS, and DPPH assays. Intracellular H2O2-scavenging activity was also performed on HaCaT cells. The results showed that phenolic compounds are the main antioxidant of the mushrooms. Among studied samples, Inonotus andersonii, and Phellinus gilvus exhibited very high antioxidant activity with the phenolic contents up to 310.8 and 258.7 mg GAE/g extracts, respectively. The H2O2-scavenging assay on cells also revealed the potential of these mushrooms in the prevention of oxidative stress. In term of ACE-inhibition, results showed that Phlebia tremellosa would be a novel and promising candidate for antihypertensive studies. This mushroom exhibited even higher in vitro ACE-inhibition activity than Ganoderma lingzhi, with the IC50 values of the two mushrooms being 32 μ g/mL and 2 μ g/mL, respectively. This is the first time biological activities of mushrooms collected in Nepal were reported. Information from this study should be a valuable reference for future studies on antioxidant and ACE-inhibitory activities of mushrooms.

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Идентификаторы

DOI: 10.1155/2014/195305

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Показатели — AkademScholar