Статья

The bactericidal effect of silver nanoparticles

José Rubén Morones‐RamírezDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USAJose Luis ElechiguerraDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USAAlejandra CamachoTexas Materials Institute, University of Texas at Austin, Austin, TX 78712, USAKatherine B. HoltDepartment of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USAJuan B. KouríDepartamento de Patología Experimental, Centro de Investigaciones y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro de Zacatenco, CP 07360, México DF, MexicoJosé Tapia-Ramı́rezDepartamento de Genética y Biología Molecular, Centro de Investigaciones y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro de Zacatenco, CP 07360, México DF, MexicoMiguel José YacamánDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA

2005en

ABI

Аннотация

Nanotechnology is expected to open new avenues to fight and prevent disease using atomic scale tailoring of materials. Among the most promising nanomaterials with antibacterial properties are metallic nanoparticles, which exhibit increased chemical activity due to their large surface to volume ratios and crystallographic surface structure. The study of bactericidal nanomaterials is particularly timely considering the recent increase of new resistant strains of bacteria to the most potent antibiotics. This has promoted research in the well known activity of silver ions and silver-based compounds, including silver nanoparticles. The present work studies the effect of silver nanoparticles in the range of 1-100 nm on Gram-negative bacteria using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM). Our results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.

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Идентификаторы

DOI: 10.1088/0957-4484/16/10/059

Цитирования и источники

Цитирований: 18Использованных источников: 0

Показатели — AkademScholar