Endophyte fungal isolate mediated biogenic synthesis and evaluation of biomedical applications of silver nanoparticles

The present investigation aims to explore therapeutic potential of biogenic synthesised silver nanoparticles (AgNPs) mediated using endophytic fungus extract isolated from Tinospora cordifolia. The synthesised AgNPs characterised using various physicochemical analyses. In FTIR, amide I and II bands of protein and hydroxyl groups of phenolic hydroxyl confirming bioactive metabolites presence over AgNPs surface. The mean size of AgNPs found 25–35 nm spherical in size. Further, AgNPs demonstrated higher antibacterial, antioxidant, and anti-inflammatory activity than endophyte fungal extract. Such high activity of AgNPs might be a resultant of the propounding synergistic activity of silver nanoparticle and endophyte bioactive metabolites over AgNPs surface that is confirmed by FTIR. Moreover, antiproliferative activity in cervical and breast cancer cells was demonstrated. Finally, AgNPs found cytocompatibility and hemocompatibility. Thus, the results obtained provide apparent and multiple biological activities of biogenic silver nanoparticles synthesised as possible multipurpose therapeutic material with little systemic toxicity.

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