Статья

Portable air-fed cold atmospheric plasma device for postsurgical cancer treatment

Guojun ChenCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USAZhitong ChenDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USAZejun WangCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USARichard ObenchainDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USADi WenCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USAHongjun LiCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USARichard E. WirzDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USAZhen GuCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA

2021en

ABI

Аннотация

Surgery represents the major option for treating most solid tumors. Despite continuous improvements in surgical techniques, cancer recurrence after surgical resection remains the most common cause of treatment failure. Here, we report cold atmospheric plasma (CAP)–mediated postsurgical cancer treatment, using a portable air-fed CAP (aCAP) device. The aCAP device we developed uses the local ambient air as the source gas to generate cold plasma discharge with only joule energy level electrical input, thus providing a device that is simple and highly tunable for a wide range of biomedical applications. We demonstrate that local aCAP treatment on residual tumor cells at the surgical cavities effectively induces cancer immunogenic cell death in situ and evokes strong T cell–mediated immune responses to combat the residual tumor cells. In both 4T1 breast tumor and B16F10 melanoma models, aCAP treatment after incomplete tumor resection contributes to inhibiting tumor growth and prolonging survival.

Перевод пока недоступен

Идентификаторы

DOI: 10.1126/sciadv.abg5686

Цитирования и источники

Цитирований: 4Использованных источников: 0

Показатели — AkademScholar