Cell death affecting the progression of gastric cancer
Haoying WangDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaMengxiao LiuDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaXi ZengDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaYa ZhengDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, ChinaYuping WangDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. [email protected]Yongning ZhouDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. [email protected]
2022en
ABI
Аннотация
Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an important element. In this review, we summarized the effects of necrosis, apoptosis, necroptosis, pyroptosis, ferroptosis, and eight less common cell death modalities on gastric cancer cells and the tumor microenvironment, detailed the molecular mechanisms of various cell death and their major regulatory pathways in gastric cancer, explored the prevalence and complexity of cell death in gastric cancer progression and highlighted the potentials of cell death-related therapies in gastric cancer.
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