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Exploring the Use of Cold Atmospheric Plasma to Overcome Drug Resistance in Cancer

Dzohara MurilloInstituto Universitario de Oncología del Principado de Asturias, 33006 Oviedo, SpainCarmen HuergoInstituto Universitario de Oncología del Principado de Asturias, 33006 Oviedo, SpainBorja GallegoInstituto Universitario de Oncología del Principado de Asturias, 33006 Oviedo, SpainRené Rodrı́guezCIBER en Oncología (CIBERONC), 28029 Madrid, SpainJuan TornínInstituto Universitario de Oncología del Principado de Asturias, 33006 Oviedo, Spain
2023en
ABI

Аннотация

Drug resistance is a major problem in cancer treatment, as it limits the effectiveness of pharmacological agents and can lead to disease progression. Cold atmospheric plasma (CAP) is a technology that uses ionized gas (plasma) to generate reactive oxygen and nitrogen species (RONS) that can kill cancer cells. CAP is a novel approach for overcoming drug resistance in cancer. In recent years, there has been a growing interest in using CAP to enhance the effectiveness of chemotherapy drugs. In this review, we discuss the mechanisms behind this phenomenon and explore its potential applications in cancer treatment. Going through the existing literature on CAP and drug resistance in cancer, we highlight the challenges and opportunities for further research in this field. Our review suggests that CAP could be a promising option for overcoming drug resistance in cancer and warrants further investigation.

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