Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells

As an emerging kind of crystalline material, the metal-organic framework (MOF) has shown great promise in the biomedical domains such as drug storage and delivery. In this study, a new porous MOF, [[Dy 2 (H 2 O) 3 (SDBA) 3 ](DMA) 6 ] ( 1 , H 2 SDBA = 4,4′-sulfonyldibenzoic acid, DMA = N , N -dimethylacetamide (C 4 H 9 NO)), with uncoordinated O donor sites has been fabricated using a bent polycarboxylic acid organic linker under the solvothermal condition. The structure of the obtained crystalline product has been fully determined by the X-ray single-crystal diffraction, TGA, elemental analysis, XRD, and the gas sorption measurement. Due to the suitable window size and polar atom functionalized 1D channels, the activated 1 ( 1a ) compound was used for the anticancer drug 5-fluorouracil (5-Fu, C 4 H 3 FN 2 O 2 ) loading by a simple impregnation method. A moderate drug loading and pH-dependent drug-release behavior could be observed for 1a . Furthermore, as indicated by the MTT assay, this drug/MOF composite shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against the human osteosarcoma cell line MG63.

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