Статья

Carbon Quantum Dots Conjugated Rhodium Nanoparticles as Hybrid Multimodal Contrast Agents

Giovanni Marco SaladinoDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology, SE-10691 Stockholm, SwedenNuzhet I. KilicDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology, SE-10691 Stockholm, SwedenBertha BrodinDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology, SE-10691 Stockholm, SwedenBejan HamawandiDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology, SE-10691 Stockholm, Swedenİdris YazganCenter of Biosensors and Materials, Department of Biology, Faculty of Science and Arts, Kastamonu University, Kastamonu 37150, TurkeyHans M. HertzDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology, SE-10691 Stockholm, SwedenMuhammet S. ToprakDepartment of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology, SE-10691 Stockholm, Sweden

2021en

ABI

Аннотация

Nanoparticle (NP)-based contrast agents enabling different imaging modalities are sought for non-invasive bio-diagnostics. A hybrid material, combining optical and X-ray fluorescence is presented as a bioimaging contrast agent. Core NPs based on metallic rhodium (Rh) have been demonstrated to be potential X-ray Fluorescence Computed Tomography (XFCT) contrast agents. Microwave-assisted hydrothermal method is used for NP synthesis, yielding large-scale NPs within a significantly short reaction time. Rh NP synthesis is performed by using a custom designed sugar ligand (LODAN), constituting a strong reducing agent in aqueous solution, which yields NPs with primary amines as surface functional groups. The amino groups on Rh NPs are used to directly conjugate excitation-independent nitrogen-doped carbon quantum dots (CQDs), which are synthesized through citrate pyrolysis in ammonia solution. CQDs provided the Rh NPs with optical fluorescence properties and improved their biocompatibility, as demonstrated in vitro by Real-Time Cell Analysis (RTCA) on a macrophage cell line (RAW 264.7). The multimodal characteristics of the hybrid NPs are confirmed with confocal microscopy, and X-ray Fluorescence (XRF) phantom experiments.

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Идентификаторы

DOI: 10.3390/nano11092165

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar