Статья

The Impact of Bilateral Stone Disease on Patients' Disease Progression and Health-Related Quality of Life

Brendan L. RaizenneDivision of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, CanadaClaudia DeyirmendjianFaculty of Medicine, Université de Montréal, Montréal, CanadaMarie-Lyssa LafontaineFaculty of Medicine, Université de Montréal, Montréal, CanadaMaimouna BaldeFaculty of Sciences and Technologies, Gaston Berger University, Saint Louis, SenegalSeth K. BechisDepartment of Urology, University of California San Diego, San Diego, California, USARoger L. SurDepartment of Urology, University of California San Diego, San Diego, California, USAStephen Y. NakadaDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USAJodi AntonelliDivision of Urology, Department of Surgery, Duke University, Durham, North Carolina, USANecole M. StreeperDivision of Urology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USASri SivalingamGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USADavis P. ViprakasitDepartment of Urology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USATimothy D. AverchDepartment of Urology, Palmetto Health USC Medical Group, Columbia, South Carolina, USAJaime LandmanUniversity of California Irvine School of Medicine, Orange, California, USAThomas ChiDepartment of Urology, University of California San Francisco, San Francisco, California, USAVernon M. PaisUrology Section, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USABen H. ChewDepartment of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, CanadaVincent G. BirdDepartment of Urology, University of Florida College of Medicine, Gainesville, Florida, USASero AndonianDivision of Urology, McGill University Health Center, Montreal, CanadaNoah CanvasserDepartment of Urology, University of California Davis, Sacramento, California, USAJonathan D. HarperDepartment of Urology, University of Washington, Seattle, Washington, USAKristina L. PennistonDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USANaeem BhojaniDivision of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Canada

2023en

ABI

Аннотация

Purpose: Patients with recurring kidney stone events can expect significant morbidity and functional impairment. Few studies have evaluated the effect of bilateral kidney stones on disease progression and quality of life. We wanted to determine the association of bilateral stone disease on age of onset, and the impact on number of stone events and individual kidney stone disease-specific health-related quality of life (HRQOL) by analyzing the validated and prospectively collected Wisconsin Stone Quality of Life (WISQOL) database. Materials and Methods: We studied 2906 stone patients from 16 centers in North America after having completed the WISQOL questionnaire from 2014 to 2019. Kidney stone formers were assessed if kidney stones were bilateral or unilateral on imaging. Analysis with a chi-square test compared categorical variables. Bilateral kidney stone disease and its impact on HRQOL were evaluated through a multivariable linear regression model. Results: Of 2906 kidney stone formers, 1340 had unilateral kidney stones and 1566 had bilateral kidney stones. We observed more frequently that patients with bilateral stones had an increased number of depression/anxiety symptoms, renal tubular acidosis, and rheumatoid arthritis (all p < 0.05). Patients with bilateral stones had a younger mean (standard deviation [SD]) age of kidney stone disease onset (37.2 ± 15.8 vs 46.4 ± 15.9 years of age, p < 0.001). Bilateral kidney stone formers had a higher mean (SD) number of stone events (11.3 ± 21.8) than unilateral kidney stone formers (3.0 ± 5.1) (p < 0.001). Within our multivariable analysis, we found that HRQOL was negatively affected by the presence of bilateral stones for kidney stone patients (β = −11.2 [confidence interval: −19.5 to −3.0] points, p < 0.05). Conclusions: Bilateral kidney stone formers had a younger age of kidney stone disease onset and a higher number of stone events compared with unilateral kidney stone disease formers. The presence of bilateral kidney stone disease negatively impacted HRQOL.

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Идентификаторы

DOI: 10.1089/end.2023.0132

Цитирования и источники

Цитирований: 2Использованных источников: 0

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