Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease: The Emerging Role of VDAC
Pierpaolo RisiglioneDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 64, 95125 Catania, ItalyFederica ZinghirinoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 64, 95125 Catania, ItalyMaria Carmela Di RosaDepartment of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 64, 95125 Catania, ItalyAndrea MagrìDepartment of Biological, Geological and Environmental Sciences, University of Catania, Via Santa Sofia 64, 95125 Catania, ItalyAngela MessinaDepartment of Biological, Geological and Environmental Sciences, University of Catania, Via Santa Sofia 64, 95125 Catania, Italy
2021en
ABI
Аннотация
Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including αSyn. This review analyzes the main aspects of αSyn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.
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