Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme–substrate binding
Deliang ChenJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, ChinaYibao LiJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, ChinaXun LiJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, ChinaXuechuan HongState Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and Hubei Province, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, ChinaXiaolin FanJiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, ChinaTor SavidgeDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA
2022en
ABI
Аннотация
and the mechanism of enhancing atomic charge densities. Our findings may help resolve the debate between TS stabilization and GS destabilization and assist our understanding of catalysis and the design of artificial enzymes.
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