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Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Mohammad ChehelgerdiNovin Genome (NG) Institute, Research and Development Center for Biotechnology, Shahrekord, Chaharmahal and Bakhtiari, IranMatin ChehelgerdiNovin Genome (NG) Institute, Research and Development Center for Biotechnology, Shahrekord, Chaharmahal and Bakhtiari, IranOmer Qutaiba B. AllelaDepartment of Pharmacy, Al-Noor University College, Nineveh, IraqRenzon Daniel Cosme PechoDepartment of Biochemistry, Universidad San Ignacio de Loyola (USIL), Lima, PeruJ. NarayananDepartment of Pharmacology, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, Kattankulathur, Tamil Nadu, 603203, IndiaDevendra Pratap RaoTamilanban ThamaraikaniDepartment of Pharmacology, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, Kattankulathur, Tamil Nadu, 603203, IndiaManimaran VasanthanDepartment of Pharmaceutics, SRM Institute of Science and Technology, SRM College Of Pharmacy, Chengalpattu District, Kattankulathur, Tamil Nadu, 603203, IndiaPatrik ViktorKeleti Károly Faculty of Business and Management, Óbuda University, Tavaszmező U. 15-17, 1084, Budapest, HungaryNatrayan LakshmaiyaDepartment of Mechanical Engineering, Saveetha School of Engineering, SIMATS, Chennai, Tamil Nadu, IndiaMohamed J. SaadhFaculty of Pharmacy, Middle East University, Amman, 11831, JordanAyesha AmajdDepartment of Mechanical Engineering, CEMMPRE, University of Coimbra, Polo II, 3030-788, Coimbra, PortugalMabrouk A. Abo‐ZaidDepartment of Biology, College of Science, Jazan University, 82817, Jazan, Saudi ArabiaRoxana Yolanda Castillo-AcoboUniversidad Nacional de San Agustin de Arequipa, Arequipa, PeruAhmed IsmailDepartment of Biology, College of Science, Jazan University, 82817, Jazan, Saudi ArabiaAli H. AminDeanship of Scientific Research, Umm Al-Qura University, Makkah, 21955, Saudi ArabiaReza Akhavan‐SigariDepartment of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Warsaw, Poland
2023en
ABI

Аннотация

The use of nanotechnology has the potential to revolutionize the detection and treatment of cancer. Developments in protein engineering and materials science have led to the emergence of new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers for medicinal purposes have been approved for human trials, only a few have been authorized for clinical use in targeting cancer cells. In this review, we analyze some of the authorized formulations and discuss the challenges of translating findings from the lab to the clinic. This study highlights the various nanocarriers and compounds that can be used for selective tumor targeting and the inherent difficulties in cancer therapy. Nanotechnology provides a promising platform for improving cancer detection and treatment in the future, but further research is needed to overcome the current limitations in clinical translation.

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