Обзорная статья

Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis

Binglin YueKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaHaiyan YangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaJian WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaWenxiu RuKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaJiyao WuKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaYongzhen HuangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaXianyong LanKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaChuzhao LeiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling ChinaHong ChenKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province College of Animal Science and Technology Northwest A&F University Yangling China

2020en

ABI

Аннотация

Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most mammalian cell types and then released. Exosomes are effective carriers for the intercellular material transfer of material that can influence a series of physiological and pathological processes in recipient cells. Among loaded cargoes, non-coding RNAs (ncRNAs) vary for the exosome-producing cell and its homeostatic state, and characterization of the biogenesis and secretion of exosomal ncRNAs and the functions of these ncRNAs in skeletal muscle myogenesis remain preliminary. In this review, we will describe what is currently known of exosome biogenesis, release and uptake of exosomal ncRNAs, as well as the varied functions of exosomal miRNAs in skeletal muscle myogenesis.

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Идентификаторы

DOI: 10.1111/cpr.12857

Цитирования и источники

Цитирований: 4Использованных источников: 0

Показатели — AkademScholar