Статья

Retracted: M2 Macrophage–Derived Exosomes Facilitate HCC Metastasis by Transferring αMβ2 Integrin to Tumor Cells

Jindao WuHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaWen GaoDepartment of Oncology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaQiyun TangDepartment of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaYue YuHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaWei YouDepartment of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaZhengshan WuDepartment of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaYe FanDepartment of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaLong ZhangHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaChen WuHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaGuoyong HanHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaXueliang ZuoHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaYao ZhangHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaZhiqiang ChenHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaWenzhou DingHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaXiangcheng LiHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaFengming LinThe State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing,ChinaHongbing ShenDepartment of Epidemiology and Biostatistics,Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment,Collaborative Innovation Center for Cancer Personalized Medicine,School of Public Health,Nanjing Medical University,Nanjing,ChinaJinhai TangDepartment of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaYaqin ZhangHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,ChinaXuehao WangHepatobiliary Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China

2020en

ABI

Аннотация

Background and Aims The development and progression of hepatocellular carcinoma (HCC) is dependent on its local microenvironment. Tumor‐associated macrophages (TAMs) are deemed a key factor for the tumor microenvironment and attribute to contribute to tumor aggressiveness. However, the detailed mechanism underlying the pro‐metastatic effect of TAMs on HCC remains undefined. Approach and Results The present study proved that TAMs were enriched in HCC. TAMs were characterized by an M2‐polarized phenotype and accelerated the migratory potential of HCC cells in vitro and in vivo . Furthermore, we found that M2‐derived exosomes induced TAM‐mediated pro‐migratory activity. With the use of mass spectrometry, we identified that integrin, α M β 2 (CD11b/CD18), was notably specific and efficient in M2 macrophage–derived exosomes (M2 exos). Blocking either CD11b and/or CD18 elicited a significant decrease in M2 exos–mediated HCC cell metastasis. Mechanistically, M2 exos mediated an intercellular transfer of the CD11b/CD18, activating the matrix metalloproteinase‐9 signaling pathway in recipient HCC cells to support tumor migration. Conclusions Collectively, the exosome‐mediated transfer of functional CD11b/CD18 protein from TAMs to tumor cells may have the potency to boost the migratory potential of HCC cells, thus providing insights into the mechanism of tumor metastasis.

Перевод пока недоступен

Идентификаторы

DOI: 10.1002/hep.31432

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar