Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Joshua A WelshTranslational Nanobiology Section, Laboratory of Pathology National Cancer Institute, National Institutes of Health Bethesda Maryland USADeborah C. I. GoberdhanNuffield Department of Women's and Reproductive Health University of Oxford, Women's Centre, John Radcliffe Hospital Oxford UKLorraine O’DriscollSchool of Pharmacy and Pharmaceutical Sciences Trinity College Dublin Dublin IrelandEdit I. BuzásDepartment of Genetics, Cell‐ and Immunobiology Semmelweis University Budapest HungaryCherie BlenkironFaculty of Medical and Health Sciences The University of Auckland Auckland New ZealandBenedetta BussolatiDepartment of Molecular Biotechnology and Health Sciences University of Turin Turin ItalyHoujian CaiUniversity of Georgia Athens Georgia USADolores Di VizioDepartment of Surgery, Division of Cancer Biology and Therapeutics Cedars‐Sinai Medical Center Los Angeles California USATom A. P. DriedonksDepartment CDL Research University Medical Center Utrecht Utrecht The NetherlandsUta ErdbrüggerUniversity of Virginia Health System Charlottesville Virginia USAJuan Manuel Falcón‐PérezExosomes Laboratory, Center for Cooperative Research in Biosciences Basque Research and Technology Alliance Derio SpainQing‐Ling FuExtracellular Vesicle Research and Clinical Translational Center The First Affiliated Hospital, Sun Yat‐sen University Guangzhou ChinaAndrew F. HillInstitute for Health and Sport Victoria University Melbourne AustraliaMetka LenassiFaculty of Medicine University of Ljubljana Ljubljana SloveniaSai Kiang LimParacrine Therapeutics Pte. Ltd., Singapore, SingaporeMỹ G. MahoneyThomas Jefferson University Philadelphia Pennsylvania USASujata MohantyStem Cell Facility All India Institute of Medical Sciences New Delhi IndiaAndreas MöllerChinese University of Hong Kong Hong Kong Hong Kong S.A.RRienk NieuwlandAmsterdam Vesicle Center, Amsterdam University Medical Centers, Location AMC University of Amsterdam Amsterdam The NetherlandsTakahiro OchiyaTokyo Medical University Tokyo JapanSusmita SahooIcahn School of Medicine at Mount Sinai New York New York USAAna Cláudia TorrecilhasLaboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários, Departamento de Ciências Farmacêuticas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas Universidade Federal de São Paulo (UNIFESP) Campus Diadema Diadema BrazilLei ZhengDepartment of Laboratory Medicine, Nanfang Hospital Southern Medical University Guangzhou ChinaAndries ZijlstraDepartment of Pathology Vanderbilt University Medical Center Nashville Tennessee USASarah AbuelreichDepartment of Molecular Medicine, Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte California USAReem BagabasDepartment of Molecular Medicine, Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte California USAPaolo BergeseCenter for Colloid and Surface Science (CSGI) Florence ItalyEsther BridgesWeatherall Institute of Molecular Medicine University of Oxford Oxford UKMarco BrucaleConsiglio Nazionale delle Ricerche ‐ Istituto per lo Studio dei Materiali Nanostrutturati Bologna ItalyDylan BurgerDepartment of Cellular and Molecular Medicine University of Ottawa Ottawa CanadaRandy P. CarneyDepartment of Biomedical Engineering University of California Davis California USAEmanuele CocucciComprehensive Cancer Center The Ohio State University Columbus Ohio USARossella CrescitelliSahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg Gothenburg SwedenEdveena HanserDepartment of Biomedicine University Hospital Basel Basel SwitzerlandAdrian L. HarrisDepartment of Oncology University of Oxford Oxford UKNorman J. HaugheyDepartments of Neurology and Psychiatry Johns Hopkins University School of Medicine Baltimore Maryland USAAn HendrixCancer Research Institute Ghent Ghent BelgiumAlexander R. IvanovBarnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology Northeastern University Boston Massachusetts USATijana Jovanović‐TalismanDepartment of Cancer Biology and Molecular Medicine, Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte California USANicole A. Kruh‐GarciaBio‐pharmaceutical Manufacturing and Academic Resource Center (BioMARC) Infectious Disease Research Center, Colorado State University Fort Collins Colorado USAVroniqa Ku'ulei‐Lyn FaustinoDepartment of Molecular Medicine, Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte California USADiego KyburzDepartment of Biomedicine University of Basel Basel SwitzerlandCecilia LässerKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition Institute of Medicine at Sahlgrenska Academy, University of Gothenburg Gothenburg SwedenKathleen M. LennonDepartment of Molecular Medicine, Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte California USAJan LötvallKrefting Research Centre, Institute of Medicine at Sahlgrenska Academy University of Gothenburg Gothenburg SwedenAdam L. MaddoxDepartment of Molecular Medicine, Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte California USAElena S. Martens‐UzunovaErasmus MC Cancer Institute University Medical Center Rotterdam, Department of Urology Rotterdam The NetherlandsRachel R. MizenkoDepartment of Biomedical Engineering University of California Davis California USALauren A. NewmanCollege of Medicine and Public Health Flinders University Adelaide AustraliaAndrea RidolfiDepartment of Physics and Astronomy, and LaserLaB Amsterdam Vrije Universiteit Amsterdam Amsterdam The NetherlandsEva RohdeDepartment of Transfusion Medicine, University Hospital Salzburger Landeskliniken GmbH of Paracelsus Medical University Salzburg AustriaTatu RojalinDepartment of Biomedical Engineering University of California Davis California USAAndrew RowlandCollege of Medicine and Public Health Flinders University Adelaide AustraliaAndrás SafticsDepartment of Molecular Medicine, Beckman Research Institute City of Hope Comprehensive Cancer Center Duarte California USAUrsula S. SandauDepartment of Anesthesiology & Perioperative Medicine Oregon Health & Science University Portland Oregon USAJulie A. SaugstadDepartment of Anesthesiology & Perioperative Medicine Oregon Health & Science University Portland Oregon USAFaezeh ShekariCeler Diagnostics Toronto CanadaSimon SwiftWaipapa Taumata Rau University of Auckland Auckland New ZealandDmitry Ter‐OvanesyanWyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts USAJuan Pablo TosarInstitut Pasteur de Montevideo Montevideo UruguayZivile UseckaiteCollege of Medicine and Public Health Flinders University Adelaide AustraliaFrancesco ValleConsiglio Nazionale delle Ricerche ‐ Istituto per lo Studio dei Materiali Nanostrutturati Bologna ItalyZoltán VargaBiological Nanochemistry Research Group Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences Budapest HungaryEdwin van der PolAmsterdam Vesicle Center, Amsterdam University Medical Centers, Location AMC University of Amsterdam Amsterdam The NetherlandsMartijn J. C. van HerwijnenDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The NetherlandsMarca H. M. WaubenDepartment of Biomolecular Health Sciences, Faculty of Veterinary Medicine Utrecht University Utrecht The NetherlandsAnn M. WehmanUniversity of Denver Denver USAS WilliamsInternational Society for Extracellular VesiclesAndrea ZendriniCenter for Colloid and Surface Science (CSGI) Florence ItalyAlan ZimmermanBarnett Institute of Chemical and Biological Analysis, Department of Chemistry and Chemical Biology Northeastern University Boston Massachusetts USAClotilde ThéryCurieCoreTech Extracellular Vesicles, Institut Curie Paris FranceKenneth W. WitwerDepartment of Molecular and Comparative Pathobiology Johns Hopkins University School of Medicine Baltimore Maryland USA
2024en
ABI
Аннотация
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.
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