Статья

Long circulation and tumor-targeting biomimetic nanoparticles for efficient chemo/photothermal synergistic therapy

Yifan ZhangSchool of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Xinjiang, Shihezi 832003, ChinaXuanyu YueSchool of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Xinjiang, Shihezi 832003, ChinaShengchao YangSchool of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Xinjiang, Shihezi 832003, ChinaXianglong LiLab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. ChinaLin CuiSchool of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Xinjiang, Shihezi 832003, ChinaXiaobin CuiSchool of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Xinjiang, Shihezi 832003, ChinaYue ShiShenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, ChinaZhiyong LiuSchool of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Xinjiang, Shihezi 832003, ChinaXuhong GuoSchool of Chemistry and Chemical Engineering, Shihezi University/Key Laboratory of Green Process for Chemical Engineering/Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region/Engineering Center for Chemical Materials of Xinjiang Bingtuan, Shihezi University, Xinjiang, Shihezi 832003, ChinaYongsheng LiLab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China

2022en

ABI

Аннотация

Photothermal therapy combined with chemotherapy based on nanomedicine has been considered a promising strategy for improving therapeutic efficacy in a tumor. However, nanomedicine can be easily cleared by the immune system without specific surface engineering modifications, thus affecting the ultimate efficacy. Herein, multifunctional biomimetic nanoparticles (Bio-RBCm@PDA@MSN-DOX) with enhanced long circulation and targeting ability are constructed by coating large pore-sized mesoporous silica (MSN) with polydopamine (PDA) layers in a biotin modified red blood cell membrane (Bio-RBCm) for efficient chemo/photothermal synergistic therapy. It is demonstrated that Bio-RBCm@PDA@MSN-DOX presents high photothermal conversion efficiency (40.17%) and enhanced capability to accelerate the release of the anticancer drug (doxorubicin, DOX), thus showing a good synergistic therapeutic effect in cell experiments. More importantly, with the assistance of the biotin and RBC membrane, Bio-RBCm@PDA@MSN-DOX can successfully evade immune clearance and effectively target transport to HeLa tumor sites, finally accomplishing up to 98.95% tumor inhibition with negligible side effects to normal tissues. This multilayer structure presents a valuable model for future therapeutic applications with safe and effective tumor chemotherapy and photothermal therapy.

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Идентификаторы

DOI: 10.1039/d2tb00748g

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar