Статья

Electro‐compacted collagen for corneal epithelial tissue engineering

Zhi ChenARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong Fairy Meadow New South Wales AustraliaXiao LiuARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong Fairy Meadow New South Wales AustraliaJingjing YouLions New South Wales Eye Bank and New South Wales Bone Bank New South Wales Organ and Tissue Donation Service Sydney New South Wales AustraliaEva Tomaskovic‐CrookARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong Fairy Meadow New South Wales AustraliaZhilian YueARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong Fairy Meadow New South Wales AustraliaAlireza TalaeiARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong Fairy Meadow New South Wales AustraliaGerard SuttonChatswood Clinic Vision Eye Institute Sydney New South Wales AustraliaJeremy M. CrookARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong Fairy Meadow New South Wales AustraliaGordon G. WallaceARC Centre of Excellence for Electromaterials Science Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong Fairy Meadow New South Wales Australia

2023en

ABI

Аннотация

Bioengineered corneal substitutes offer a solution to the shortage of donor corneal tissue worldwide. As one of the major structural components of the cornea, collagen has shown great potential for tissue-engineered cornea substitutes. Herein, free-standing collagen membranes fabricated using electro-compaction were assessed in corneal bioengineering application by comparing them with nonelectro-compacted collagen (NECC). The well-organized and biomimetic fibril structure resulted in a significant improvement in mechanical properties. A 10-fold increase in tensile and compressive modulus was recorded when compared with NECC membranes. In addition to comparable transparency in the visible light range, the glucose permeability of the electro-compacted collagen (ECC) membrane is higher than that of the native human cornea. Human corneal epithelial cells adhere and proliferate well on the ECC membrane, with a large cell contact area observed. The as-described ECC has appropriate structural, topographic, mechanical, optical, glucose permeable, and cell support properties to provide a platform for a bioengineered cornea; including the outer corneal epithelium and potentially deeper corneal tissues.

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Идентификаторы

DOI: 10.1002/jbm.a.37500

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Цитирований: 2Использованных источников: 0

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