A Biomimetic, Bilayered Antimicrobial Collagen-Based Scaffold for Enhanced Healing of Complex Wound Conditions
Matthew McGrathAdvanced Materials and BioEngineering Research (AMBER) Centre, RCSI and TCD, Dublin D02 PN40, IrelandKarolina ZimkowskaRegenerative Medicine Institute, University of Galway, Galway H91 TK33, IrelandKatelyn J. GenoudAdvanced Materials and BioEngineering Research (AMBER) Centre, RCSI and TCD, Dublin D02 PN40, IrelandJack MaughanAdvanced Materials and BioEngineering Research (AMBER) Centre, RCSI and TCD, Dublin D02 PN40, IrelandJavier Gutierrez GonzalezAdvanced Materials and BioEngineering Research (AMBER) Centre, RCSI and TCD, Dublin D02 PN40, IrelandS. BrowneTissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephen’s Green, Dublin D02 YN77, IrelandFergal J. O’BrienAdvanced Materials and BioEngineering Research (AMBER) Centre, RCSI and TCD, Dublin D02 PN40, Ireland
2023en
ABI
Аннотация
and supporting the proliferation of epidermal cells on its surface. This bilayered scaffold also demonstrated the ability to support the proliferation of key cell types involved in vascularization, namely, induced pluripotent stem cell derived endothelial cells and supporting stromal cells, with early signs of organization of these cells into vascular structures, showing great promise for the promotion of angiogenesis. Taken together, the results indicate that the bilayered scaffold is an excellent candidate for enhancement of diabetic wound healing by preventing wound infection and supporting angiogenesis.
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