Integrative Analysis Identified CD38 As a Key Node That Correlates Highly with Immunophenotype, Chemoradiotherapy Resistance, And Prognosis of Head and Neck Cancer
Zhengxi HeCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, 410011, ChinaChunxue YueDepartment of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Jinan, Shandong, 250022, ChinaXiuwen ChenTeaching and Research Section of Clinical Nursing, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, ChinaXin LiBreast Cancer Center, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, ChinaLi ZhangChangsha Medical University, Changsha, Hunan, 410219, ChinaShan TanChangsha Medical University, Changsha, Hunan, 410219, ChinaXia YiChangsha Medical University, Changsha, Hunan, 410219, ChinaGengqiu LuoDepartment of Pathology, Xiangya Hospital, Basic School of Medicine, Central South University, Changsha, Hunan, 410008, ChinaYanhong ZhouCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, 410011, China
2023en
ABI
Аннотация
is a key gene involved in radiotherapy, chemotherapy, and immune drug resistance in HNC. This study provides a reliable biomarker to predict the prognosis of patients with HNC and a reference for clinical comprehensive treatment of HNC. Individualization combined with CD38 monoclonal antibodies might provide a promising treatment strategy for this fatal disease, and this comprehensive treatment might reduce the damage to normal tissue and improve the prognosis and quality of life of patients with HNC.
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