MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis
Stefano AliverniniInstitute of Rheumatology - Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, ItalyElisa GremeseInstitute of Rheumatology - Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, ItalyCharles McSharryInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United KingdomBarbara TolussoInstitute of Rheumatology - Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, ItalyGianfranco FerraccioliInstitute of Rheumatology - Fondazione Policlinico Universitario A. Gemelli, Catholic University of the Sacred Heart, Rome, ItalyIain B. McInnesInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United KingdomMariola Kurowska‐StolarskaInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
2018en
ABI
Аннотация
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.
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