Ghrelin
Timo D. MüllerInstitute for Diabetes and Obesity, Helmholtz Zentrum München, München, GermanyRubén NogueirasDepartment of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, University of Santiago de Compostela (CIMUS)-Instituto de Investigación Sanitaria (IDIS)-CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainMark L. AndermannDivision of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USAZane B. AndrewsDepartment of Physiology, Faculty of Medicine, Monash University, Melbourne, Victoria, AustraliaStefan D. AnkerApplied Cachexia Research, Department of Cardiology, Charité Universitätsmedizin Berlin, GermanyJesús ArgenteDepartment of Pediatrics and Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain ; Department of Pediatrics, Universidad Autónoma de Madrid and CIBER Fisiopatología de la obesidad y nutrición, Instituto de Salud Carlos III, Madrid, SpainRachel L. BatterhamCentre for Obesity Research, University College London, London, United KingdomS.C. BenoitMetabolic Disease Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USAC. Y. BowersTulane University Health Sciences Center, Endocrinology and Metabolism Section, Peptide Research Section, New Orleans, LA, USAFabio BroglioDivision of Endocrinology, Diabetes and Metabolism, Dept. of Medical Sciences, University of Torino, Torino, ItalyFelipe F. CasanuevaDepartment of Medicine, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS), CIBER de Fisiopatologia Obesidad y Nutricion (CB06/03), Instituto Salud Carlos III, Santiago de Compostela, SpainDavid A. D’AlessioDuke Molecular Physiology Institute, Duke University, Durham, NC, USAInge DepoortereTranslational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, BelgiumAllan GeliebterColumbia UniversityEzio GhigoDepartment of Pharmacology & Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USAPhilip A. ColeMonash Obesity & Diabetes Institute, Monash University, Clayton, Victoria, AustraliaMichael A. CowleyDepartment of Physiology, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia ; Monash Obesity & Diabetes Institute, Monash University, Clayton, Victoria, AustraliaD. E. CummingsDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USAAlain DagherMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, CanadaSabrina DianoDept of Neurobiology, Yale University School of Medicine, New Haven, CT, USASuzanne L. DicksonDepartment of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SwedenCarlos DiéguezDepartment of Physiology, School of Medicine, Instituto de Investigacion Sanitaria (IDIS), University of Santiago de Compostela, SpainRiccarda GranataDivision of Endocrinology, Diabetes and Metabolism, Dept. of Medical Sciences, University of Torino, Torino, ItalyHarvey J. GrillDepartment of Psychology, Institute of Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA, USAKelly GroveDepartment of Diabetes, Obesity and Metabolism, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USAKirk M. HabeggerComprehensive Diabetes Center, University of Alabama School of Medicine, Birmingham, AL, USAKristy M. HeppnerDivision of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USAMark L. HeimanNuMe Health, 1441 Canal Street, New Orleans, LA 70112, USALaura M. HolsenDepartments of Psychiatry and Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USABirgitte HolstDepartment of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen N, DenmarkAkio InuiDepartment of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanJ-O JanssonInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SwedenHenriette KirchnerMedizinische Klinik I, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Lübeck, GermanyMárta KorbonitsCentre for Endocrinology, William Harvey Research Institute, Barts and the London, Queen Mary University of London, London, UKBlandine LaferrèreNew York Obesity Research Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USAC.W. LeRouxDiabetes Complications Research Centre, Conway Institute, University College Dublin, IrelandMiguel LópezDepartment of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, University of Santiago de Compostela (CIMUS)-Instituto de Investigación Sanitaria (IDIS)-CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, SpainSophie MorinInstitute for Diabetes and Obesity, Helmholtz Zentrum München, München, GermanyMichiko NakazatoDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, JapanRalf NassDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, USADiego Pérez–TilveDepartment of Internal Medicine, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USAPaul T. PflugerInstitute for Diabetes and Obesity, Helmholtz Zentrum München, München, GermanyThue W. SchwartzDepartment of Neuroscience and Pharmacology, Laboratory for Molecular Pharmacology, The Panum Institute, University of Copenhagen, Copenhagen, DenmarkRandy J. SeeleyDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USAMark W. SleemanDepartment of Physiology, Faculty of Medicine, Monash University, Melbourne, Victoria, AustraliaYuxiang SunChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USALori SusselDepartment of Genetics and Development, Columbia University, New York, NY, USAJenny TongDuke Molecular Physiology Institute, Duke University, Durham, NC, USAMichael O. ThornerDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, USAA. J. van der LelyDepartment of Medicine, Erasmus University MC, Rotterdam, The NetherlandsL. H. T. Van der PloegRhythm Pharmaceuticals, Boston, MA, USAJeffrey M. ZigmanDepartments of Internal Medicine and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USAMasayasu KojimaMolecular Genetics, Institute of Life Science, Kurume University, Kurume, JapanKenji KangawaNational Cerebral and Cardiovascular Center Research Institute, Osaka, JapanR G SmithThe Scripps Research Institute, Florida Department of Metabolism & Aging, Jupiter, FL, USATamás L. HorváthProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USAM. TschöpInstitute for Diabetes and Obesity, Helmholtz Zentrum München, München, Germany ; Division of Metabolic Diseases, Department of Medicine, Technical University Munich, Munich, Germany
2015en
ABI
Аннотация
BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.
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