Статья

L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors

Kwangsoo KimDepartment of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of KoreaJae‐Ho JeongDepartment of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of KoreaDaejin LimDepartment of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of KoreaYeongjin HongDepartment of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of KoreaHyung-Ju LimDepartment of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of KoreaGeun-Joong KimDepartment of Biological Sciences, College of Natural Sciences, Chonnam National University , Gwangju, KoreaSo-ra ShinDepartment of Biological Sciences, College of Natural Sciences, Chonnam National University , Gwangju, KoreaJe-Jung LeeDepartment of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of Korea; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Jeollanamdo, Republic of KoreaMisun YunDepartment of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of Korea; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanamdo, Republic of KoreaRobert A. HarrisRoudebush VA Medical Center and the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine , Indianapolis, Indiana, USAJung-Joon MinDepartment of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of Korea; Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanamdo, Republic of KoreaHyon E. ChoyDepartment of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Molecular Medicine, Chonnam National University Graduate School, Gwangju, Republic of Korea

2015en

ABI

Аннотация

Bacteria can be engineered to deliver anticancer proteins to tumors via a controlled expression system that maximizes the concentration of the therapeutic agent in the tumor. L-asparaginase (L-ASNase), which primarily converts asparagine to aspartate, is an anticancer protein used to treat acute lymphoblastic leukemia. In this study, Salmonellae were engineered to express L-ASNase selectively within tumor tissues using the inducible araBAD promoter system of Escherichia coli. Antitumor efficacy of the engineered bacteria was demonstrated in vivo in solid malignancies. This result demonstrates the merit of bacteria as cancer drug delivery vehicles to administer cancer-starving proteins such as L-ASNase to be effective selectively within the microenvironment of cancer tissue.

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Идентификаторы

DOI: 10.1038/mto.2015.7

Цитирования и источники

Цитирований: 2Использованных источников: 0

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