Обзорная статья

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

Chen LiDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaYu‐Qing NiDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaHui XuDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaQunyan XiangDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaYan ZhaoDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaJunkun ZhanDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaJieyu HeDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaShuang LiDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, ChinaYou‐Shuo LiuDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. [email protected]

2021en

ABI

Аннотация

Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.

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Идентификаторы

DOI: 10.1038/s41392-021-00779-x

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar