Обзорная статья

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Chin-Yap LohSchool of Biosciences, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47500, MalaysiaJian ChaiSchool of Biosciences, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47500, MalaysiaTing TangDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaWon Fen WongDepartment of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, MalaysiaGautam SethiDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeMuthu K. ShanmugamDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporePei Pei ChongSchool of Biosciences, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47500, MalaysiaChung Yeng LooiSchool of Biosciences, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya 47500, Malaysia

2019en

ABI

Аннотация

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients. The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin, and this process is regulated by a complex network of signaling pathways and transcription factors. In this review, we summarized the recent understanding of the roles of E- and N-cadherins in cancer invasion and metastasis as well as the crosstalk with other signaling pathways involved in EMT. We also highlighted a few natural compounds with potential anti-EMT property and outlined the future directions in the development of novel intervention in human cancer treatments. We have reviewed 287 published papers related to this topic and identified some of the challenges faced in translating the discovery work from bench to bedside.

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Идентификаторы

DOI: 10.3390/cells8101118

Цитирования и источники

Цитирований: 3Использованных источников: 0

Показатели — AkademScholar