Статья

Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

Lolita KuršvietienėDepartment of Biochemistry, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50009 Kaunas, LithuaniaDalia M. KopustinskienėInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, LithuaniaInga StanevičienėDepartment of Biochemistry, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50009 Kaunas, LithuaniaAušra MongirdienėDepartment of Biochemistry, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50009 Kaunas, LithuaniaKateřina KubováDepartment of Pharmaceutical Technology, Masaryk University, 60177 Brno, Czech RepublicRūta MasteikováDepartment of Pharmaceutical Technology, Masaryk University, 60177 Brno, Czech RepublicJurga BernatonienėDepartment of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania

2023en

ABI

Аннотация

Cancer is one of the most serious public health issues worldwide, demanding ongoing efforts to find novel therapeutic agents and approaches. Amid growing interest in the oncological applications of phytochemicals, particularly polyphenols, resveratrol-a naturally occurring polyphenolic stilbene derivative-has emerged as a candidate of interest. This review analyzes the pleiotropic anti-cancer effects of resveratrol, including its modulation of apoptotic pathways, cell cycle regulation, inflammation, angiogenesis, and metastasis, its interaction with cancer stem cells and the tumor microenvironment. The effects of resveratrol on mitochondrial functions, which are crucial to cancer development, are also discussed. Future research directions are identified, including the elucidation of specific molecular targets, to facilitate the clinical translation of resveratrol in cancer prevention and therapy.

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Идентификаторы

DOI: 10.3390/antiox12122056

Цитирования и источники

Цитирований: 2Использованных источников: 0

Показатели — AkademScholar