Статья

The conserved domain database in 2023

Jiyao WangNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAFarideh ChitsazNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAMyra K. DerbyshireNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USANoreen R. GonzalesNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAMarc GwadzNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAShennan LuNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAGabriele H. MarchlerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAJames S. SongNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USANarmada ThankiNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USARoxanne A. YamashitaNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAMingzhang YangNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USADachuan ZhangNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAChanjuan ZhengNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAChristopher J. LanczyckiNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USAAron Marchler‐BauerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda , MD 20894 , USA

2022en

ABI

Аннотация

NLM's conserved domain database (CDD) is a collection of protein domain and protein family models constructed as multiple sequence alignments. Its main purpose is to provide annotation for protein and translated nucleotide sequences with the location of domain footprints and associated functional sites, and to define protein domain architecture as a basis for assigning gene product names and putative/predicted function. CDD has been available publicly for over 20 years and has grown substantially during that time. Maintaining an archive of pre-computed annotation continues to be a challenge and has slowed down the cadence of CDD releases. CDD curation staff builds hierarchical classifications of large protein domain families, adds models for novel domain families via surveillance of the protein 'dark matter' that currently lacks annotation, and now spends considerable effort on providing names and attribution for conserved domain architectures. CDD can be accessed at https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.

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Идентификаторы

DOI: 10.1093/nar/gkac1096

Цитирования и источники

Цитирований: 2Использованных источников: 0

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