Статья

Age-related disparities in diabetes risk attributable to modifiable risk factor profiles in Chinese adults: a nationwide, population-based, cohort study

Tiange WangShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaZhiyun ZhaoShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaGuixia WangThe First Hospital of Jilin University, Changchun, ChinaQiang LiThe Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaYu XuClinical Trials Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMian LiShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaRuying HuZhejiang Provincial Center for Disease Control and Prevention, ChinaGang ChenFujian Provincial Hospital, Fujian Medical University, Fuzhou, ChinaQing SuXinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaYiming MuChinese People's Liberation Army General Hospital, Beijing, ChinaXulei TangThe First Hospital of Lanzhou University, Lanzhou, ChinaLi YanSun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaGuijun QinThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaQin WanThe Affiliated Hospital of Southwest Medical University, Luzhou, ChinaZhengnan GaoDalian Municipal Central Hospital, Dalian, ChinaXuefeng YuTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaFeixia ShenThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaZuojie LuoFirst Affiliated Hospital of GuangXi Medical UniversityYingfen QinThe First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaLi ChenQilu Hospital of Shandong University, Jinan, ChinaYanan HuoJiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, ChinaTianshu ZengUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaLulu ChenQilu Hospital of Shandong University, Jinan, ChinaZhen YeZhejiang Provincial Center for Disease Control and Prevention, ChinaYinfei ZhangCentral Hospital of Shanghai Jiading District, Shanghai, ChinaChao LiuJiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, ChinaYoumin WangThe First Affiliated Hospital of Anhui Medical University, Hefei, ChinaShengli WuKaramay Municipal People's Hospital, Xinjiang, ChinaTao YangThe First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaHuacong DengThe First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaJiajun ZhaoShandong Provincial Hospital affiliated to Shandong University, Jinan, ChinaLixin ShiYiping XuClinical Trials Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMin XuShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaYuhong ChenShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShuangyuan WangShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaJieli LuShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaYufang BiShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaGuang NingShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaWeiqing WangShanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: [email protected]

2021en

ABI

Аннотация

BACKGROUND: National investigations of age-specific modifiable risk profiles for diabetes are crucial to promote personalised strategies for the prevention and control of diabetes, particularly in countries such as China, which is experiencing both a diabetes epidemic and a rapidly ageing population. We aimed to examine the associations of 12 potentially modifiable socioeconomic, lifestyle, and metabolic risk factors with diabetes in a nationwide prospective cohort of Chinese adults across four age groups. METHODS: We analysed data from the China Cardiometabolic Disease and Cancer Cohort Study, a nationwide, population-based, cohort study done between Jan 1, 2011, and Dec 31, 2016. Among 93 781 participants without diabetes at baseline and with complete information available about risk factors and diabetes incidence, we examined the hazard ratios (HRs) and population-attributable risk percentages (PAR%s) of incident diabetes associated with 12 potentially modifiable risk factors: two socioeconomic risk factors (less education and intermediate or low grade occupation), five lifestyle risk factors (unhealthy diet, physical inactivity, current alcohol consumption, current smoking, and unhealthy sleep), and five metabolic risk factors (general or central obesity, insulin resistance, prediabetes, hypertension, and dyslipidaemia) across four age groups (40 to <55 years, 55 to <65 years, 65 to <75 years, and ≥75 years). FINDINGS: =0·016). INTERPRETATION: These findings provide novel insights into age-related modifiable risk factor profiles for diabetes in Chinese adults, highlighting the importance of prioritising risk factors according to age groups for effective prevention and management of diabetes. FUNDING: National Natural Science Foundation of China. TRANSLATION: For the Chinese translation of the abstract see Supplementary Materials section.

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DOI: 10.1016/s2666-7568(21)00177-x

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Цитирований: 3Использованных источников: 0

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